We are faced every day with complex design issues and have to make decisions on how we design our clients e-commerce interfaces. We take all the aspects of our clients site design and build very seriously especially when it comes to getting a user to click the buy it now button.
This is an interesting article about a debate that has been going on for a while in our studio, and one that we feel very passionate about getting correct.
Summary: Many design elements work for Amazon.com mainly because of its status as the world's largest and most established e-commerce site. Normal sites should not copy Amazon's design.